Surface modification of cellulose nanocrystal with chitosan oligosaccharide for drug delivery applications

A novel drug delivery system based on two of the most abundant natural biopolymers was developed by modifying the surface of oxidized cellulose nanocrystal (CNC) with chitosan oligosaccharide (CS_OS). First, the primary alcohol moieties of CNC were selectively oxidized to carboxyl groups using the 2,2,6,6-tetramethylpiperidine-1-oxyl radical catalyst. The amino groups of CS_OS were then reacted with carboxylic acid groups on oxidized CNC (CNC-OX) via the carbodiimide reaction using N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide as coupling agents. Successful grafting of CS_OS to CNC-OX was confirmed by infrared spectroscopy, thermogravimetry, potentiometric titration, and zeta potential measurements. The grafting resulted in a conversion of ~90 % carboxyl groups on CNC-OX and the degree of substitution was 0.26. CNC–CS_OS nanoparticles showed a binding efficiency of 21.5 % and a drug loading of 14 % w/w. A drug selective electrode was used to directly measure the concentration of procaine hydrochloride released from CNC–CS_OS particles. The in vitro drug release was studied at pH 8 and the nanoparticles revealed a fast release of up to 1 h, which can be used as biocompatible and biodegradable drug carriers for transdermal delivery applications.     

Synthesis and application of novel carbohydrate-based ammonium and triazolium salts

The synthesis of nine new carbohydrate-based quaternary ammonium salts and two new triazolium salts starting from d-glucose has been accomplished. Our synthesis utilized the regio- and stereoselective ring opening reaction of 2,3-anhydro sugars by nucleophilic reagents to afford the key intermediates. In these new types of phase transfer catalysts, the ammonium and triazolium functions are directly attached to the carbohydrate scaffold in different positions (2-, 3-, 6-positions of the sugar). The efficiency of the altrose- and glucose-based quaternary salts were tested in the alkylation of N-(diphenyl) methylene glycine tert-butyl ester with benzyl bromide. To our knowledge this is the first example when sugar-based quaternary ammonium or triazolium salts were used successfully as phase transfer catalysts. The enantiomeric recognition ability of the synthesized salts towards racemic Mosher’s acid silver salt was also investigated by ¹⁹F NMR spectroscopy.     

A New Route to 16-Methylene-17-ketosteroids

A new, high-yield preparation of 16-methylene-17-ketosteroids by the methylenation of trimethylsilyl enol ethers is described.     

Design of a dual-core dual-hole fiber for hydrostatic pressure sensing

We propose a novel dual-core dual-hole fiber (DCDHF) for hydrostatic pressure sensing. Two fiber cores and two air holes are employed in the cross-section of the DCDHF. The mode coupling between two fiber cores of the DCDHF is sensitive to the pressure-induced index change which ensures the detection of the pressure applied to the DCDHF. Two large air holes are employed to enhance the pressure-induced index change for the DCDHF which essentially provides a built-in transducing mechanism to enhance the sensitivity for the DCDHF-based pressure sensor. The DCDHF-based pressure sensor is simply formed by splicing a segment of DCDHF to two segments of single mode fibers and its operation principle is introduced in details. Simulations show that there is a linear relationship between the pressure untilized on the DCDHF and the wavelength shift of the output spectrum at one fiber core of the DCDHF with a fixed length when the polarized light is injected into another fiber core of the DCDHF. DCDHFs with different structure parameters for pressure sensing are also investigated.     

Hydrostatic pressure sensor based on a gold-coated thin-core fiber modal interferometer and ripple shift measurement

We propose a hydrostatic pressure sensor based on a gold-coated thin-core fiber modal interferometer (TCFMI). A thin-core fiber is spliced to a single mode fiber forming a single-end fiber modal interferometer (FMI) due to the core mismatch and the fiber end reflection. Relative reflection spectra of TCFMIs based on thin-core fibers with different lengths are investigated. The TCFMI is gold-coated to enhance the optical reflectivity, which also results in the ripple of the relative reflection spectra of TCFMI. A high hydrostatic pressure sensor test system is proposed and the performance of the pressure sensor has been experimentally investigated. A pure-ripple-shift measurement method is used to achieve the demodulation of the sensor. The proposed pressure sensor has a sensing range up to 40 MPa and a sensitivity of 44.8 pm/MPa.     

利用紫外Mie散射激光雷达探测澳门地区沙尘暴事件

研制了一台工作波长为355nm的紫外高能Mie散射激光雷达,并利用该激光雷达在2010年一次沙尘暴事件期间对澳门上空的大气进行了探测,得到了澳门地区不同时刻的气溶胶消光系数垂直廓线。利用Fernald方法反演得到的气溶胶近地面消光系数随时间的变化与当地气象数据具有较好的一致性,气溶胶消光系数与当地可吸入颗粒物浓度的相关性达到了0.93。气溶胶垂直廓线显示,在沙尘暴来临期间存在明显的沙尘气溶胶凝集层。通过气溶胶轨迹倒推,分析了沙尘气溶胶的来源及路径。观测结果表明,该激光雷达可以在特殊天气条件下对澳门地区气溶胶进行有效探测,这将有助于深化对澳门上空气溶胶特性的研究。     

Annual variability in a conceptual climate model: snapshot attractors, hysteresis in extreme events, and climate sensitivity

In a conceptual model of global atmospheric circulation, the effects of annually periodic driving are investigated. The driven system is represented in terms of snapshot attractors, which may remain fractal at all times. This is due to the transiently chaotic behavior in the regular parameter regimes of the undriven system. The driving with annual periodicity is found to be relatively fast: There is a considerable deviation from the undriven case. Accordingly, the existence of a hysteresis loop is identified, namely, the extremal values of a given variable depend not only on the actual strength of the insolation but also on the sign of its temporal change. This hysteresis is due to a kind of internal memory. In the threshold-dependence of mean return times of various extreme events, a roughly exponential scaling is found. Climate sensitivity parameters are defined, and the measure of certain types of extremal behavior is found to be strongly susceptible to changes in insolation.     

A mathematical model of Schmidt corrector plate with defocus in variable for quick F ratio and large aperture systems

To make it easier for designing Schmidt optical systems, based on wavefront aberration functions, a mathematical model of the corrector plate aspheric surfaces varies as a function of defocusing amount is established. It corrects not only the third-order spherical aberration, but also the 5th-order spherical aberration for the system. A series of Schmidt optical systems were designed as examples to evaluate the mathematical model of the aspherics. Results show that the mathematical model is precisely in fitting the needed shape of the corrector, and can be used for the systems for quick F ratio and large aperture. A mathematical model for reflective correctors shape is also established.     

Quantum nonlocality does not imply entanglement distillability

Entanglement and nonlocality are both fundamental aspects of quantum theory, and play a prominent role in quantum information science. The exact relation between entanglement and nonlocality is, however, still poorly understood. Here we make progress in this direction by showing that, contrary to what previous work suggested, quantum nonlocality does not imply entanglement distillability. Specifically, we present analytically a 3-qubit entangled state that is separable along any bipartition. This implies that no bipartite entanglement can be distilled from this state, which is thus fully bound entangled. Then we show that this state nevertheless violates a Bell inequality. Our result also disproves the multipartite version of a long-standing conjecture made by Peres.     

A Markov-Nikolskii type inequality for absolutely monotone polynomials of order <Emphasis Type="Italic">K</Emphasis>

A function Q is called absolutely monotone of order k on an interval I if Q(x) ≥ 0, Q′(x) ≥ 0, …, Q(k)(x) ≥ 0, for all x ε I. An essentially sharp (up to a multiplicative absolute constant) Markov inequality for absolutely monotone polynomials of order k in L _p [−1, 1], p > 0, is established. One may guess that the right Markov factor is cn ²/k, and this indeed turns out to be the case. Similarly sharp results hold in the case of higher derivatives and Markov-Nikolskii type inequalities. There is also a remarkable connection between the right Markov inequality for absolutely monotone polynomials of order k in the supremum norm and essentially sharp bounds for the largest and smallest zeros of Jacobi polynomials. This is discussed in the last section of the paper.